Which topical vaginal estrogen preparation is known for having the highest dose?

The vaginal rings are recognized for delivering a consistent and higher dose of estrogen compared to other topical preparations like creams and tablets. The ring releases estrogen over a prolonged period, typically up to three months, which allows for a steady absorption of the hormone, making it particularly effective for treating menopausal symptoms such as vaginal dryness, atrophy, and other related issues.

In contrast, creams and vaginal tablets generally provide lower doses and can have varying absorption rates. The vaginal ring's method of delivery also offers convenience, as it does not require daily application like creams, making it a preferred choice for many women needing long-term estrogen therapy.

Understanding the pharmacokinetics—how the body absorbs, distributes, metabolizes, and excretes a drug—helps highlight why the vaginal ring is superior in delivering a higher consistent dose over time compared to other products.