Which of the following is a risk associated with hormone replacement therapy?

Hormone replacement therapy (HRT) is often used to alleviate symptoms associated with menopause, but it is important to recognize that it comes with certain risks. One significant risk associated with HRT is the increased likelihood of developing breast cancer. Various studies have indicated a correlation between long-term use of combined estrogen and progestin therapy and an elevated risk of breast cancer. This relationship underscores the importance of individualized treatment decisions, weighing the benefits of symptom relief against the potential risks.

In contrast, factors such as cholesterol levels and osteoporosis are typically managed through different means and demonstrating an increased risk of cholesterol reduction or a decreased risk of weight gain is not accurately associated with HRT. Similarly, while HRT can improve bone density and lower the risk of osteoporosis, it does not guarantee a lower chance of developing this condition. Understanding HRT's possible complications is crucial for healthcare providers when advising patients considering this treatment for menopausal symptoms.