What is the effect on the testosterone/SHBG ratio during menopause?

Menopause is associated with significant hormonal changes, including alterations in the levels of androgens and sex hormone-binding globulin (SHBG). As women transition into menopause, there is typically a decline in ovarian function, leading to lower levels of estrogen and testosterone.

The testosterone/SHBG ratio is important because SHBG binds to testosterone, making it less available for use by the body. During menopause, the decrease in estrogen levels often results in an increase in SHBG production. Consequently, with lower testosterone levels and higher SHBG levels, the testosterone/SHBG ratio decreases. This change is significant as it reflects the hormonal balance that occurs during this stage in a woman's life.

The assertion that the testosterone/SHBG ratio increases by 80% inaccurately represents the physiological changes occurring at menopause, indicating a misunderstanding of how these hormones interact. Instead, the hormonal dynamics are such that the ratio indeed shifts due to these changes, leading to a decrease in the ratio, which could significantly affect symptoms related to menopause.

Understanding the hormonal interplay during menopause is essential, as it can influence treatment decisions and management strategies for menopausal symptoms.