What is a potential coexisting condition found in 20-30% of patients with Paget's disease?

In Paget's disease, a potential coexisting condition that is found in 20-30% of patients is breast, gastrointestinal (GI), or genitourinary (GU) cancer. This association stems from the fact that Paget's disease primarily affects the bones, particularly the pelvis, skull, spine, and legs. However, there is a substantial prevalence of certain cancers in patients with Paget's disease, particularly breast cancer, which has been widely studied.

The relationship between Paget's disease and malignancies may be attributed to the underlying pathophysiology of abnormal bone metabolism and remodeling that could predispose individuals to cancers in adjacent areas. Additionally, the increased bone turnover seen in Paget's disease could potentially create an environment conducive to tumor development.

Understanding this association is essential for health professionals, as it underscores the importance of monitoring for cancers in patients diagnosed with Paget's disease. Awareness of these potential coexisting conditions can lead to more comprehensive patient care and appropriate screening measures.