What happens to the level of SHBG during the menopause transition?

During the menopause transition, the level of sex hormone-binding globulin (SHBG) typically increases. This rise in SHBG is closely associated with the changes in hormonal levels that occur during this period. As estrogen levels decline, there is a shift in the balance of hormones, which leads to an increase in circulating SHBG produced by the liver. Elevated SHBG levels can affect the availability of free testosterone and estrogen in the body, impacting various physiological functions.

The changes in SHBG can have significant implications for how the body metabolizes these hormones during menopause, contributing to various symptoms and health concerns associated with this transition. Understanding the role of SHBG in menopause is crucial for managing symptoms and tailoring treatment approaches effectively.