What happens to the level of SHBG during the menopause transition?

During the menopause transition, the levels of Sex Hormone-Binding Globulin (SHBG) typically increase. SHBG is a glycoprotein produced by the liver that binds to sex hormones, including testosterone and estradiol, which helps regulate their bioavailability in the body.

As women approach menopause, there is a decline in estrogen production due to reduced ovarian function. This drop in estrogen can stimulate an increase in SHBG levels. Higher SHBG levels result in decreased free testosterone and estradiol, impacting hormonal balance and potentially influencing various symptoms and conditions associated with menopause.

Understanding the behavior of SHBG during menopause is crucial for healthcare providers as it can help them interpret hormonal assessments and the potential implications for managing menopause-related symptoms and overall health.