Hormone replacement therapy primarily aims to supplement which hormones?

Hormone replacement therapy (HRT) primarily focuses on supplementing estrogen and progesterone. This approach is especially relevant for women experiencing menopause, as the body undergoes a significant decrease in these hormones during this transition. Estrogen plays a vital role in regulating various physiological functions and protecting against bone loss, cardiovascular disease, and other health concerns that may arise after menopause. Progesterone, on the other hand, is important for balancing the effects of estrogen and is essential in cases where a woman still has her uterus, as it helps to prevent endometrial hyperplasia.

While testosterone, cortisol, adrenaline, and thyroid hormones play critical roles in overall health, they are not the primary focus of HRT designed specifically for menopausal symptoms. Testosterone therapy might be considered in some cases, but it is not a standard part of HRT. Similarly, cortisol and adrenaline are part of the body's stress response, and thyroid hormones are involved in metabolism regulation. However, these do not directly address the hormonal deficiencies or symptoms related to menopause. Therefore, the correct answer recognizes the central role of estrogen and progesterone in HRT for menopausal women.