As ovarian follicles deplete, what is the consequence for follicle growth?

As ovarian follicles deplete during the transition into menopause, the physiological changes that occur ultimately lead to a restraint on follicle growth rather than stimulation. When the ovarian reserve decreases, the remaining follicles become less responsive to hormonal signals, particularly Follicle Stimulating Hormone (FSH). This means that the growth and maturation of follicles become more limited.

Over the course of this transition, the body experiences changes in hormone levels, with decreased estrogen production due to the fewer follicles being available. This also contributes to irregularities in the menstrual cycle and challenges in establishing consistent follicle growth. While there might be some cases of follicles attempting to grow, the overall process cannot be considered stimulated due to the lack of adequate hormonal support and the overall depletion of follicles.

Additionally, as menopause approaches, the potential for follicle growth does not entirely cease; rather, it becomes inconsistent and less effective. The majority of the ovarian follicles no longer respond as they did during the reproductive years. Therefore, the most accurate understanding of the situation is that follicle growth is restrained due to the depletion of ovarian follicles.